6-OXO Review

October 22nd, 2007 by Paul Johnson

6-OXO came on the market a few years ago. It revolutionized testosterone boosting in a effective, yet safe way.

About 6-OXO:

6-OXO is the brand name by ergopharm, for a aromatase inhibitor compound named 3,6,17-androstenetrione (4 etioallocholen-3,6, 17-trione). It was the first legitimate legal aromatase inhibitor available in the supplement industry. Before this, there were only prescriptions or junk herbs that didn't work.

How 6-OXO works:

Aromotase inhibitors block the conversion of testosterone to estrogen, similiar to the prescription drug arimidex. 3,6,17 androstenetrione is more specifically, a suicide aromatase inhibitor because it permanently binds together. As a result your system estrogen levels go down, but your testosterone levels should go up dramatically. If you want your estrogen levels to return to normal, then you can stop taking 6-OXO and eventually your body will replace the aromatase enzymes, restoring normal estrogen levels.

While estrogen is seen as an evil by most bodybuilders against muscle gains, it is also beneficial in moderate amounts. Therefore cycling 6-OXO to boost testosterone levels, probably will not benefit you further in muscle gains. 6-OXO and other anti-aromatase inhibitors, have not shown much benefit in increasing muscle gains in clinical studies. This is probably due to the lowering of estrogen, which is crucial in muscle gains. You can read more about estrogen's actions on muscle gain and fat loss in 2 previous articles of mine.

- Estrogen's anabolic effects

- Estrogen's fat loss effects

Increasing well above the recommended dosages, would also probably cause a rebound effect, due to overcompensation. Therefore, it is best to stay within the normal dosages, to not cause extremely low estrogen or a rebound.

When should you take 6-OXO?

After a pro-hormone or steroid cycle, 6-OXO should help increase your testosterone levels back to normal. 6-OXO is an alternative to nolva, clomid, and other prescription anti-estrogens post-cycle.

Does 6-OXO really work?

6-OXO was developed by the Patrick Arnold, a world expert in supplement and steroid chemistry. He has also developed many other hormonal products over the years including 1-AD and 11-OXO 6-OXO is also naturally found in the body as a metabolite (Steroids. 1965; 5:479-493) and in the placenta(Biochem Biophys Res Commun. 1984 Feb 14;118(3):805-13), thereby making it legal as a supplement. Bodybuilders have been using it for years now, with significant increases in strength and muscle gains in a short period of time. Multiple studies have shown this compound works as a anti-armotase in the body including one published in (J Steroid Biochem. 1987 Sep;28(3):337-44) and (J Med Chem. 1985 Jun;28(6):788-95). A study done on castrated rats (J Endocrinol. 1978 Oct;79(1):69 76.) showed this compound increased testosterone levels.

If you are trying to restore your normal natural testosterone levels after a pro-hormone or steroid cycle, then 6-OXO will work well. Although Ergopharm markets it as a testosterone booster for increasing muscle and strength gains, there is no evidence to suggest it would also be beneficial in that regard.

  1. Muscle Man on September 4th, 2008

    Nothing builds muscle like eating a ton of lean calories and protein. There are no shortcuts. Even if you juice you still need to eat and train like a mutha!

  2. Mark on April 28th, 2009

    Anything designed by Patrick Arnold you can be sure to work. I’ve tried many other over the counter anti-estrogens and 6-oxo worked the best to restore my testosterone levels post cycle.