11-OXO Review

11-oxo is one of the hottest bodybuilding supplements to hit the market in recent years. What differentiates it from any other supplement is it’s unique ability to block cortisol. Cortisol is that nasty hormone that breaks down muscle in the body and promote fat gain. It is released during weightlifting, high stress, and waking up in the morning. By controlling cortisol levels, 11-oxo helps you build more muscle and accumulate less fat during bulking.

How 11-oxo works on cortisol:

11-Oxo real name is Adrenosterone. It is of the class called first selective inhibitor of 11b hydroxysteroid dehydrogenase type I reductase. This basically means it blocks cortisone from attaching to the 11HSD1R and converting to cortisol, by 11-oxo attaching to 11HSD1R itself instead. This mechanism is called competitive inhibition.

Apparently, 11-oxo is naturally released in the androgen glands as a counter-balance to controlling cortisol, which is also released by the andrenal glands. Adrenosterone was discovered by Patrick Arnold, world renowned steroid expert and chemist, while researching in past research study texts.

Is 11-OXO a pro-hormone?

In addition to being a cortisol blocker, 11-OXO also acts as a pro-hormone, by converting to an active steroid 11-oxotestosterone in the body. This means it can be suppressive to your testosterone production and must be cycled. However, cortisol has a suppressive effect on testosterone product, therefore the cortisol blocking effects should help offset a bit the testosterone suppression from the pro-hormone conversion.

11-OXO results:

Thousands of bodybuilders have tried 11-oxo and have seen great results. There is a lot of research to backup 11-OXO, unlike most other bodybuilding supplements. Patrick Arnold is the only true authority in bodybuilding supplement research and he has researched this compound well. There are other compounds found naturally or artificially that can block cortisol through various ways, but 11-OXO has the safest and most effect route of doing it. While bulking, 11-OXO can help you bust through a plateau and gain a few lbs of muscle and make the gains more leaner. While dieting, 11-OXO can help you lose more fat and less of it being muscle.

Can Yohimbine Transdermals Spot Reduce Fat?

One common myth that floats around to people who don’t know much about fat loss, is the idea of spot reduction. This is the belief that you can lose fat in one area, by doing excercises for it. For example, some think if you do situps, it helps reduce fat around your stomach area. This has been debunked along time ago and fat is actually lost over the entire body in layers. There are certain areas of your body that have a higher preference for storing fat, but excercising certain muscles more won't help it lose fat faster than normal. In fact, the areas that gain fat first and the easiest, tend to be the last to lose the fat when dieting.

But what if I told you spot reducing fat was still possible?

Under normal conditions spot reducing is not possible, however a herb called Yohimbine could actually help. I'll tell you how.

What is Yohimbine

Yohimbine is a common fat loss stimulant used by bodybuilders for years. It has also been used commercially in pharmaceutical grade for treating sexual dysfunction in men. Yohimbine is a natural herb that has the unique ability to work on A2 receptors in fat cells as a alpha2-adrenergic receptor antagonist. Alpha 2 receptors tell the body to stop producing adrenaline. When Yohimbine blocks these receptors as an "antagonist", it keeps adrenaline from binding to the A2 receptors to stop fat oxidation (fat loss) in the cell.

How does Yohimbine spot reduce fat?

Initially, when losing fat a lot of it comes off easily. After you lose a bit of fat you start getting to more and more stubborn estrogenic fat that is leftover. This more stubborn fat tends to have a high A2 receptor density. The fat is very hard to get off because it is resistant to fat loss because of the high density of A2 receptors. High A2 receptor fat is usually in locations, such as chest, inner thighs, and love handles. Estrogen levels, genetics, and your bodyfat level dertermines both for men and women, how much of this type of fat forms. This is one reason why these areas are most "stubborn" to fat loss.

Taking the unique properties of yohimbe into consideration, Yohimbine transdermals were developed. The transdermals releases high doses of Yohimbe locally through the skin to be absorbed. Because Yohimbine is a stimulant, you can't take high doses orally. The transdermal allows you to absorb a high concentration of Yohimbine straight to where you want it to go, fat cells with high A2 receptor concentration.

Yohimbine Transdermal directions:

The use of transdermals for delivering supplements into the body is not something new. They have been used in the past by bodybuilders for other supplements including pro hormones. Some create their own transdermals and add the yohimbine to it. With yohimbine transdermals, you simply rub the lotion over the area you want to spot reduce the fat.

The best time to use Yohimbine transdermals is when you have low bodyfat and just can't get rid of fat from certain problem areas. If you are fat all over, there is no point in trying to spot reduce fat in one area with a yohimbine transdermal. Your first priority should be to just get your bodyfat low. You don't need to try and get stubborn fat, if you have plenty of other types of fat in the body. Once you get to a low bodyfat % and you hit a fat loss plateau, then add Yohimbe transdermal to the problem areas. You should start to lose the fat in those areas as long as you continue to diet and excercise while using it.

Where can I find yohimbe transdermals?

Popular commercial Yohimbine transdermal products are Lipoderm-Ultra and Lipoderm-Y w/ Caffeine by Avant labs. Some people even create their own custom yohimbine transdermal homebrews.

Do Nitric Oxide (No2) Supplements work?

The last 5 years there has been an absolute craze in the bodybuilding supplement industry over Nitric Oxide (NO2) supplements. Many bodybuilders have not looked at the research and just listened to what other bodybuilders or supplement companies have said. The supplement companies promise increased muscle growth, pumps, vascularity, and even sexual benefits. However, NO supplements may really be the biggest supplement scam to ever hit the bodybuilding industry.

What are NO (Nitric Oxide) supplements?

NO supplements contain some form of arginine, an amino acid. There are many different forms of arginine compounds in the NO supplements today, promising to be better than the other. The goal of NO supplements are to have the arginine break down into NO (Nitric Oxide) into the blood. Arginine can break down into the bloodstream by enzymatic action, into citruline and Nitric Oxide. NO is a vasodilator and is thought to play a role in muscle building. There is some research showing NO levels increase post workout, leading some bodybuilders to believe it is crucial to protein synthesis. Many have theorized that because NO supplements increase blood flow due to NO in the blood, that increased blood flow from NO leads to better muscle growth. NO in the blood is also the same mechanism by which viagra works too.

NO (Nitric Oxide) studies

There is not one single legitimate scientific study showing NO2 supplements taken orally directly increase NO levels in the blood by a significant level. Yes, that is right you have all have been duped by the supplement companies and bodybuilding "gurus" for years now!

Now I did mention earlier, arginine does convert to NO so, why doesn't arginine supplements increase NO in the blood? Arginine indeed does increase NO levels in the blood, but only when taken intravaneously. Why? Because if you took the doses orally that required a big increase in NO, you would be a vomiting mess. Arginine causes extreme nausea at high doses, that is why all the studies at high doses were done intravaneously. Unfortunately, the upper limit for oral doses, doesn't seem to increase NO levels much.

Extenze and Magna-RX Male Enhancement Pill Reviews

Every few months there is a new “male enhancement” pill showing up on T.V. The newest fads are ExtenZe and Magna-Rx+. Although they call them male enhancement pills, the advertisements lead you to think they are for penis enlargement and increasing erection strength and stamina. At least that is what they are supposed to do. Some supplement manafacturers have gotten sued over making similiar claims in the past. Is Extenze or Magna-RX anything different than these past male enhancement pills or is it just the same hype under a new name?

Extenze Review:

The easiest way to know if something works is to see what the ingredients are.

Serving Size: 1 Tablet Servings Per Container: 30
Folate (Folic Acid) 400mcg
Zinc (as Oxide) 25mg

Extenze Male Prohormone Support
Micronized DHEA (dehydroepiandrosterone)
Pregnenolone (3?-hydroxypregn-5-en-20-one)

Extenze Bio-Enhancement Support
Black Pepper (seed)
Piper Longum (seed)
Ginger (root)

Extenze Sexual Responce Enhancement Support 600mg
Medically Designed, Proprietary Blend of the finest quality herbal and nutritional Sexual Response Enhancement Support Ingredients:

Yohimbe Extract (bark) Provides 12.5mg yohimbine alkaloids
Tribulus terrestris Extract (aerial part and fruit) Provides 50mg furanosterols
Korean Ginseng Extract (root) Standardized to 10% ginsenosides
Cnidium monnier (seed)
Eleutherococcus Extract (root) Standardized to .8% eleuthrosides
Xanthroparmelia scarbrosa (aerial part)
Gamma-Aminobutyric Acid - GABA
Velvet Deer Antler
Horney Goat Weed (leaf)
Damiana (leaf)
Muira puama Extract (stem)
Pumpkin (seed)
Stinging Nettle (root)
Astragalus (root)
Licorice Extract (root)
l-Arginine Hydrochloride
Ho Shou Wu Extract (root)
Hops (Strobile) Extract (blossom)
Boron (as Chelate)

Most of these herbs and minerals are pretty well known, but many are unproven and even debatable on how well they work. DHEA is a precursor to testosterone, estrogen, and other hormones and has been used by middle aged men as a hormone replacement. DHEA may give a long term benefit to boosting your sexual health through improving your hormone levels. The yohimbe extract is a popular bodybuilding stimulant used for fat loss, but it also has been used commercially for erections and sexual stamina. Yohimbe does seem to increase libido, erection strength, and sexual stamina. Tribulus terrestris extract ancedotally has been thought to be an aphrodesiac and there is some research on rats I have found, that may support that. Zinc is good for boosting testosterone levels as it prevents the conversion of testosterone to dht. It also is good for prostate health. Ginseng will only give you more energy. Velvet deer antler and horny goat weed have been for years thought of as aphrodesiacs, but how well they actually work is debateable. L-arginine is a common ingredient for bodybuilders to increase muscle building and pumps. It is thought to cause a increase in NO in the blood, dilating the vessels. This is the same mechanism by which viagra works. However, there is a lot of new research studies showing that arginine supplementation does not effect NO levels in blood unless it is intravaneously injected. Most of the other herbs are unproven and just sort of thrown together. Extenze is basically a combination of herbs, stimulants, amino acids, minerals, pro-hormones, aphrodesiacs (some that work some that probably don't), and a bunch of other herbs that probably don't work. They throw a little bit of everything, proven or unproven.

Magna-RX+ Review:

Magna-RX+ has many of the same ingredients of Extense, but not quite as many.

L-Arginine, Nettle Leaf, Cayenne, Muira Puama, OrchicSubstance, Oyster Meat, Tribulus, Zinc, Sarsparilla, Astragalus, Licorice Root, Pumpkin Seed, Boron, Pygeum, Maca, Catauba, Horney Goat Weed, Oat Straw

The biggest ingredient in Magna-RX is L-Arginine, which as said earlier doesn't work for erections.

Does Magna-RX+ and Extense work?

If your looking for something to increase your penis size, then forget it. These pills definitely won't do that, just like none of the previous "male enhancement pills" did. I think men thinking it might help increase their penis size is probably why most buy these male enhancement pills to begin with. If you want something to increase your energy, sexual stamina, and erection hardness, then ExtenZe probably could help. They add so many different ingredients, it should help you, especially if you are already struggling with weak erections or lack of stamina.

Magna-RX on the other hand probably won't do much because it contains less ingredients, most of which are unproven herbs. Their main ingredient is L-arginine, which recent research is showing just doesn't work when taken orally, for increasing NO levels in the blood to help with erections.

Glutamine Review

You may have stumbled on other Glutamine reviews at other sites and many bodybuilders raving how well glutamine preserved their muscles during cutting. This article is going to be different than most, I'm going to tell you something that I've known all along:

 

GLUTAMINE DOES NOT WORK!

 

You may wonder how I could be bold enough to flat out say all the supplement companies and people advocating it could be wrong after all these years. Let's first look at some Glutamine studies to see why I say this.

Glutamine research studies

J Strength Cond Res 17(3):425-438, 2003 published a study of 29 lifters on a strength training program. They were in 3 groups, creatine only, placebo, and glutamine and creatine. Both creatine groups gained muscle more than placebo, however no difference between the non-glutamine and the glutamine creatine combo. OK, but that is one study, why should we believe only one study? The same group actually did a seperate study, this time with ribose, glutamine, and effervescent creatine. Once again, no differences in muscle gains between the glutamine groups.

Still not convinced by these two studies?

I found a study done way back in 2001 published by Eur J Appl Physiol 86:142-149, 2001. I don't know why no one knew about this study until recently, but it would have probably changed some peoples minds about Glutamine a long time ago. The study had 31 volunteers weight train for 6 weeks. There was no differences between those who supplemented glutamine (.4 grams per lb of bodyweight) and those who took placebo (maltodextrin). So we now have 3 studies showing that glutamine has absolutely nothing to do with muscle gains.

Glutamine study during dieting

Some of you may be pointing out the fact, that glutamine has usually been only recommended for bodybuilders who are dieting, to preserve their muscle. Well, I found a study that proves that glutamine doesn't even help muscle preservation during dieting either! Another study in 2003 Published in the Journal of Sports Science and Medicine (2003) 2, 163-168 had 18 athletes for 12 days take glutamine at 0.16 g/ lb per bodyweight, while they were cutting. They saw absolutely no difference in muscle preservation between the groups.

The research overwhelmingly shows that glutamine is not good for bulking or cutting, despite almost every website and bodybuilder giving it a positive review for the last decade. I personally tried glutamine years ago during cutting and it never helped me maintain any extra muscle. I felt the science supporting glutamine was always weak anyways, bodybuilders were already on high protein diets, so taking extra glutamine isn't likely to help much no matter how hard you try to spin it.

Bodybuilding Supplement & “Legal Steroid” Scams

If you are a new to the bodybuilding world, you may not realize how many vultures are waiting on the sidelines ready to steal your money. We all at one time (and some of us still are) hoping for that magic muscle building supplement that no one knows about yet. It's in our nature to want something that causes big muscle gains, but without any side effects. I come across many small websites on the net all the time, advertising supplements that promise steroid like gains and claim to be side effect free. The sites usually use studies and testimonials to back up their product. The problem is the studies they use for these products are usually very weak and often not done on humans.

Another common trick many of these supplement sites use, is they repackage a worthless supplement under another name. In this way, they can continue to try to push a supplement with the same old argument and research at a much higher price, even though it is the same junk supplement that bodybuilders discounted years ago.

Then of course, there is the "legal steroid" websites, which try to market steroids to the gullible. They use fancy names closely resembling actual illegal steroids. The active ingredients in these rip-offs are really nothing more then common pro-hormones found on the market, but at 2 or 3 times the price. Even well known bodybuilding supplement brands, make outrageous claims that become the butt of jokes by veteran bodybuilders.

You are probably wondering why everyone is able to get away with all of this? Well, it is hard for a supplement to be proven beyond a doubt to not work. Secondly, they use very weak science or far reaching studies and they use that as justification for their claims. If you can't prove beyond a doubt it doesn't work and the company basis their claims on actual science or research, there is little that can be done.

At the moment, the only way to get a true consensus on what bodybuilding supplements may actually work, is to find out what other bodybuilders say in the forums. You can't listen to supplement companies or those bought off by them because they have a biased agenda driven by money. When listening to other bodybuilder's anecdotal experiences on supplements, you have to also remember the placebo factor too. If the overwhelming majority see results, then it probably works. Placebo strongly influences strength gains, so when deciding if a supplement works, I would pay more attention to those claiming muscle mass gains or losing fat.


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