Hormone Factor That Causes Rebound Weight Gain

September 1st, 2007 by Paul Johnson

Recent research has shown a chemical in the body called IL-6 interleukin-6 is a important hormone in regulating fat gain. IL-6 is a pro-inflammatory hormone. It promotes the same inflammatory cascade that is seen as a result of excercise. The inflammatory cascade results ultimately in increased cortisol production, which as we know increases muscle breakdown and fat gain.

British Journal of Nutrition (2006) published research done on 67 overweight people(45 women and 22 men). They were put on a weight loss program for 10 weeks. There was no statistically significant differences in weight loss between those with high or low IL-6 levels in the body. The interesting results came one year later on follow up testing. They found that those who had gained the weight back , had higher levels of IL-6 naturally than those who kept the weight off.

Researchers concluded that IL-6 may trigger regain of weight by inflammation at the fat cell. This means that bodybuilders should realize, that some people will have a harder time keeping the fat off. This is more of a concern for inconsistent amateur dieters than for experienced bodybuilders. Research also shows that a may help reduce IL-6 and control insulin levels, both beneficial for bodybuilders. You can read more about it in a previous article of mine Whole grain diet effects inflammation & insulin