No2 (nitric oxide) Supplements Review

May 24th, 2008 by Paul Johnson

Nitric Oxide is one of the most popular muscle building supplements on the market now. Can it actually help muscle gains or is it hype? What I’m about to say may surprise you.

What are NO (nitric Oxide) supplements?

NO supplements are supposed to increase Nitric Oxide in the blood. NO Supplements contain arginine, with most in the form of Arginine-alpha-keto-glutarate. Nitric Oxide has hundreds of functions in the body, especially with blood flow, nerves, and cell communication. It acts as a vasodilator(increasing blood flow) in the body by relaxing the smooth muscles. Nitric Oxide (NO) is formed when the amino acid arginine, is broken down by an enzyme into citruline.

Why do bodybuilders take NO supplements?

To get better muscle pumps, increased strength and muscle gains, and for sexual health. It is thought that nitric oxide plays a crucial role in muscle building based on some indirect studies and theory.

NO supplement studies:

It sounds like NO supplementation is a important supplement, but there is no legitimate scientific studies showing NO supplements increased strength and muscle gains. Most of the NO advocates are using indirect reasoning to support the use of NO as a muscle builder. For example, they believe that since NO could help muscle gains because of the increased blood flow to the muscles. Other studies such as published in Am J Hypertens. 2007 Aug;20(8):825-30, showed an increase in NO production after resistance excercise. This has then led some to assume, that NO may then be involved in causing increased protein synthesis post-workout.

The problem with all these assumptions is that arginine doesn't seem to convert to Nitric Oxide at the recommended dosages. If you go through all the studies done on high doses of arginine, you will see no increase in vasodilation (increased blood flow). It increases vasodilation only at high doses when injected. The reason why we can't get to those levels orally, is because it is much higher than the level that causes stomach upset. So arginine will convert to nitric oxide, just not at the dosages someone could withstand orally, without getting really sick. I suppose someone could start injecting it, but NO supplements aren't THAT good to warrant it! No legitimate scientific study I could find has been able to show a difference, in either muscle gains or strength.

Final thoughts:

NO supplements seem to be nothing more than junk. The vasodilation effects some people "experience", seems to be nothing more than placebo effect. Therefore it's not going to be a Viagra alternative either, for those who seeked arginine for helping impotence. Many reputable experts, who aren't affiliated with supplement companies, also believe NO is a waste of money.

  1. Farouk on November 1st, 2010

    i needed to read that earlier
    thank you:)

  2. Dom on November 14th, 2010

    You’re right… there is hardly, if any scientific backing on NO products that say they work. The trick is to take Arginase (the enzyme that breaks down arginine) out of the NO equation. Something many supplement manufacturers haven’t quite figured out yet. It pays to shop around, there is stuff out there that does work… just have to sort through the hype.

  3. dale on November 15th, 2010

    I have strugeled with weight all my life,i dropped from 190kg to 95kg over a 3yr period,now after many inguries the weight is coming back,i carnt train as hard as i did 4yrs ago,And eating baked beans,apricots,tuna,broccolie has with mass water input pulled body fat off,and if these type of products,provide only a placebo effect,whats your advice on dmaa?is it not a performance enhancer?i need maximum effect for the time i can move,thanks dale

  4. commander on January 4th, 2011

    hmmm, thanks for the detailed review

  5. Horny Goat Weed on February 5th, 2011

    Ive seen some good results with some NO supplements, non of those above though. Thanks for in the review.

  6. mike on February 25th, 2011

    Nice post. Supplements are just a part of getting results as you need to train hard and eat right.

  7. active on February 28th, 2011

    The most important thing is to work out or you can’t have any muscle.

  8. Ryno on March 11th, 2011

    nice review !