September 9th, 2007 by Paul Johnson

Bodybuilders have been using spironolactone as a topical to help prevent hair loss for a few years now. I decided to do some more research to find out more about spironolactone.

What is Spironolactone?

Spironolactone (also known as Aldactone) is in fact a steroid. So how can a steroid actually help prevent hair loss? Well it is a steroid in the sense of being a testosterone derivative, but is not a anabolic androgenic steroid like testosterone.

How does Spironolactone work?

Spiro's main use orally for bodybuilders has been for it's diuretic effects during contest time. It has an effect on of aldosterone, which is the body hormone that regulates sodium retention(and hence water retention). Spiro doesn't seem to work in the same mechanisms as for example propecia. Propecia works by blocking the conversion of testosterone to DHT which is the main contributor to hair loss. There is research that points to the idea that spiro competes with DHT in the hair follicle androgen receptor. In other words, it replaces a stronger androgen(DHT), with Spironolactone.

Spironolactone topicals:

As an anti-androgen it obviously would cause serious problems for bodybuilders to take it orally. Some have developed topicals to use spiro so it goes to where it is only needed, on the top of your head. There will be some leakage into the body, but most of it will stay in the scalp only.

  1. Generic Celexa on March 10th, 2008

    Makes sense! Nice article! I’ll Digg right away….